Hyperprolactinemic amenorrhea induced by metoclopamide (PrimperanR)

Secondary amenorrhea, elicited by metoclopamide (PrimperanR) induced hyperprolactinemia, was found in a 24-year-old woman. Withdrawal of the drug was followed by normalization of the hyperprolactinemia, as well as the menses. For many years metoclopamide (PrimperanR) has been used for various dyspeptic inconveniences, such as gastro-esophageal reflux, ventricular rentention and postoperative tarm-atom. Well-known secondary effects are reported to be drowsiness, uneasiness, restlessness and extra-pyramidal secondary effects in the form of acute dystom. The present case of secondary amenorrhea caused by metoclopamide (PrimperanR) induced hyperprolactinemia has been verified clinically, serologically and by treatment.