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The local cell response to human lung carcinomas
Acta Pathologica Et Microbiologica Scandinavica. Section A, Pathology
|March 1, 1981
Summary
Human lung carcinoma tissues show immune cell infiltration, including lymphocytes and macrophages, suggesting a local immune response. However, extensive necrosis correlates with weaker infiltrates, indicating complex tumor-immune interactions.
Area of Science:
- Oncology
- Immunology
- Pathology
Background:
- Non-malignant inflammatory cells play a role in tumor microenvironments.
- Understanding immune cell infiltration in lung carcinoma is crucial for prognosis.
Purpose of the Study:
- To investigate the types and distribution of non-malignant inflammatory cells in human lung carcinomas.
- To correlate inflammatory cell infiltrates with tumor necrosis and lymphocyte subtypes.
Main Methods:
- Histochemical and immunohistochemical analysis of 21 human lung carcinoma tissue sections and cell suspensions.
- Quantification of lymphocytes, macrophages, plasma cells (IgG, IgA, IgM), and mast cells.
- Assessment of T-lymphocyte and B-lymphocyte percentages within tumor-infiltrating lymphocytes.
Main Results:
- All tumors exhibited infiltration by lymphocytes, macrophages, plasma cells, and mast cells.
- Central tumor necrosis was associated with neutrophils and macrophages, while mononuclear infiltrates were weaker in necrotic areas.
- Tumor-infiltrating lymphocytes comprised 3-67% T-lymphocytes (mean 37%) and 4-32% B-lymphocytes (mean 19%), with some discrepancies compared to peripheral blood T-lymphocyte levels.
Conclusions:
- The presence of T-lymphocytes and macrophages suggests a local anti-tumor immune response.
- Plasma cells in all tumors indicate local immunoglobulin production, potentially affecting cellular immunity.
- Tumor necrosis inversely correlates with beneficial mononuclear cell infiltration.