Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The "metabolically-obese," normal-weight individual

N B Ruderman, S H Schneider, P Berchtold

    The American Journal of Clinical Nutrition
    |August 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Reduced postprandial bone resorption and greater rise in GLP-1 in overweight and obese individuals after an α-glucosidase inhibitor: a double-blinded randomized crossover trial.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2021
    Same author

    Circulating zearalenone and its metabolites differ in women due to body mass index and food intake.

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2018
    Same author

    Three doses of vitamin D, bone mineral density, and geometry in older women during modest weight control in a 1-year randomized controlled trial.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2016
    Same author

    Influence of vitamin D and estrogen receptor gene polymorphisms on calcium absorption: BsmI predicts a greater decrease during energy restriction.

    Bone·2015
    Same author

    Vitamin D supplementation during short-term caloric restriction in healthy overweight/obese older women: Effect on glycemic indices and serum osteocalcin levels.

    Molecular and cellular endocrinology·2015
    Same author

    Hormonal and dietary influences on true fractional calcium absorption in women: role of obesity.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2012
    Same journal

    Associations of red blood cell fatty acids with personality traits: 10-year follow-up in the Kibbutzim Family Study.

    The American journal of clinical nutrition·2026
    Same journal

    Corrigendum to: Vitamin D status and breast cancer in Saudi Arabian women: case-control study [Am J Clin Nutr 98 (2013) 105-110].

    The American journal of clinical nutrition·2026
    Same journal

    High postprandial endotoxemia is associated with recurrence of cardiovascular events in patients with coronary heart disease: from the CORDIOPREV randomized clinical trial.

    The American journal of clinical nutrition·2026
    Same journal

    Reply to Wu et al.: "Nitrate and nitrite food composition database: an update and extensive deep dive".

    The American journal of clinical nutrition·2026
    Same journal

    Reframing Basic Experimental Studies in Humans-Implications for Nutrition Science.

    The American journal of clinical nutrition·2026
    Same journal

    Inconvenient for the investigator but convenient for science: trial registration in The American Journal of Clinical Nutrition.

    The American journal of clinical nutrition·2026
    See all related articles

    Many individuals with conditions like type II diabetes and hypertension may benefit from caloric restriction, even if not clinically obese. This suggests underlying metabolic factors like hyperinsulinism could be key indicators for treatment success.

    Area of Science:

    • Metabolic disorders
    • Obesity research
    • Clinical nutrition

    Background:

    • Adult-onset obesity is linked to type II diabetes, hypertension, and hypertriglyceridemia.
    • These conditions often improve with caloric restriction.
    • Standard obesity criteria may not identify all individuals who could benefit from dietary changes.

    Purpose of the Study:

    • To propose that non-obese individuals with certain metabolic disorders may also respond to caloric restriction.
    • To identify potential characteristics of such individuals, including hyperinsulinism and increased fat cell size.
    • To explore the role of inactivity and exercise as potential therapeutic interventions.

    Main Methods:

    • Review of existing literature on obesity, metabolic disorders, and caloric restriction.

    Related Experiment Videos

  • Hypothesizing potential physiological markers (hyperinsulinism, fat cell size) in non-obese individuals.
  • Considering the role of lifestyle factors like physical activity.

    • Main Results:

    • Individuals with type II diabetes, hypertension, and hypertriglyceridemia often improve with caloric restriction.
    • It is proposed that some non-obese individuals with these disorders may also benefit from caloric restriction.
    • Hyperinsulinism and increased fat cell size are suggested as potential characteristics of this subgroup.

    Conclusions:

    • Caloric restriction may be beneficial for a broader population than currently recognized, including some non-obese individuals.
    • Identifying hyperinsulinism and increased fat cell size could help target therapy.
    • Exercise may be a crucial intervention for individuals whose condition is linked to inactivity.