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Subendothelial electron-dense deposits in pulmonary alveolar wall in pulmonary actinomycosis
The American Review of Respiratory Disease
|June 1, 1981
Abstract:
Pulmonary actinomycosis is characterized by an extensive interstitial fibrosis of the lung in addition to granulomatous disease. I examined the fibrotic lung tissue of actinomycosis by electron microscopy and found subendothelial electron-dense deposits in the alveolar capillary wall. The meaning of this finding is discussed concerning the pathogenesis of interstitial fibrosis in pulmonary actinomycosis.
Insights
Pulmonary actinomycosis causes lung fibrosis. Electron microscopy revealed electron-dense deposits in alveolar capillaries, suggesting a role in fibrosis development.
Area of Science:
- Pulmonary Medicine
- Pathology
- Microbiology
Background:
- Pulmonary actinomycosis presents with interstitial lung fibrosis and granulomatous disease.
- The exact mechanisms driving fibrosis in this condition remain incompletely understood.