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Related Experiment Videos

Abnormal esophageal manometry in globus hystericus

T C Flores, F S Cross, R D Jones

    The Annals of Otology, Rhinology, and Laryngology
    |July 1, 1981
    PubMed
    Summary

    Globus sensation, often called a "lump in the throat," may stem from esophageal motility issues, not psychic causes. Studies show hypertonic and uncoordinated esophageal activity can trigger this referred sensation.

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    Area of Science:

    • Gastroenterology
    • Otolaryngology
    • Psychosomatic Medicine

    Background:

    • Globus hystericus, a sensation of a lump in the throat, is traditionally attributed to psychological factors.
    • True difficulty swallowing (dysphagia) is typically absent in patients with globus syndrome.
    • Organic causes are often presumed but require thorough investigation.

    Purpose of the Study:

    • To investigate the potential organic basis of globus syndrome.
    • To explore the role of esophageal motor activity in globus sensation.
    • To identify physiological mechanisms underlying the globus symptom.

    Main Methods:

    • Studied twelve patients diagnosed with globus syndrome.
    • Conducted physical examinations, laryngoscopy, esophagoscopy, and cineesophagograms to rule out organic causes.
    • Assessed esophageal resting pressures and motor activity in the esophageal body.

    Main Results:

    • Organic causes were successfully ruled out in all patients.
    • Ten patients exhibited significantly elevated esophageal resting pressures.
    • Nine patients demonstrated disordered motor activity within the esophagus.

    Conclusions:

    • The globus sensation may be a referred symptom originating from the esophagus.
    • Esophageal hypertonicity and incoordination are proposed as the underlying physiological cause.
    • This challenges the purely psychogenic origin of globus syndrome.

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