[Biological equivalence study of chlortetracycline preparations used in veterinary medicine]

The biological availability of chlortetracycline oral preparations used in veterinary biovit-80, biovetin and chlortetracycline) was studied on pigs. It was found that a single administration of biovit-80 or biovetin in a dose of 25,000 units kg of the body weight calculated for the chemically pure antibiotic did not provide sufficiently high therapeutic levels of the antibiotic in the blood of the pigs. The dose of biovetin biologically equivalent to 25,000 units/kg of chlortetracycline hydrochloride was 62 500 units/kg and exceeded the recommended one by 2.5 times, while equivalent dose of biovit-80 exceeded the recommended one by more than 2.5 times.