[Physiochemical characteristics of 3 states of the nystatin molecule]

Conditions for production of nystation in three main states, i.e. inert, native and activated were determined. It was found that nystatin used in medical practice is in the inert state which is most stable for this antibiotic. Under certain conditions this state is transferred into the native or activated state. Solid forms can be prepared. The native and activated states are significantly less stable. The physicochemical characteristics of these nystatin states are presented. The data obtained can be used for the development of effective methods for nystatin production and purification.