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Comparative pharmacokinetics of cyclacillin and amoxicillin in infants and children
Antimicrobial Agents and Chemotherapy
|June 1, 1981
Insights
Cyclacillin serum concentrations were similar in fasted and milk-fed infants. Cyclacillin showed faster absorption and clearance than amoxicillin in infants.
Area of Science:
- Pharmacology
- Pediatric Medicine
- Drug Metabolism
Background:
- Antibiotic efficacy in infants is crucial for treating bacterial infections.
- Understanding drug absorption and disposition in pediatric populations is essential for optimizing treatment.
- Cyclacillin and amoxicillin are commonly prescribed beta-lactam antibiotics.
Purpose of the Study:
- To compare the serum concentrations of cyclacillin in fasted versus milk-fed infants.
- To evaluate the pharmacokinetic profile of cyclacillin relative to amoxicillin in infants.
Main Methods:
- Infants received oral doses of cyclacillin suspension (25 mg/kg).
- Serum cyclacillin concentrations were measured over a 6-hour period.
- Pharmacokinetic parameters were compared between fasted and milk-fed groups and with amoxicillin data (15 mg/kg).
Main Results:
- Serum cyclacillin concentrations were comparable in both fasted and milk-fed infants.
- Cyclacillin demonstrated more rapid absorption compared to amoxicillin.
- Higher peak serum concentrations and faster clearance of cyclacillin were observed versus amoxicillin.
Conclusions:
- Feeding status (fasted vs. milk-fed) does not significantly impact cyclacillin serum concentrations in infants.
- Cyclacillin exhibits a favorable pharmacokinetic profile in infants, with rapid absorption and clearance.
- Cyclacillin may offer an advantage over amoxicillin in terms of achieving therapeutic drug levels more quickly in pediatric patients.
Abstract:
Concentrations of cyclacillin in serum over a 6-h period were similar in fasted and milk-fed infants who received 25-mg/kg doses of cyclacillin suspension. Measured by the concentration in serum after oral administration of 15-mg/kg doses, cyclacillin was absorbed more rapidly, reached larger concentrations, and was cleared more promptly than was amoxicillin.