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Interaction between vancomycin and rifampin against Staphylococcus aureus

C Watanakunakorn, J C Guerriero

    Antimicrobial Agents and Chemotherapy
    |June 1, 1981
    PubMed
    Summary
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    Vancomycin and rifampin showed antagonistic effects against most Staphylococcus aureus strains. This interaction was observed in both methicillin-susceptible and methicillin-resistant strains, impacting treatment strategies.

    Area of Science:

    • Microbiology
    • Infectious Diseases
    • Pharmacology

    Background:

    • Staphylococcus aureus is a significant human pathogen.
    • Methicillin-resistant Staphylococcus aureus (MRSA) poses a major public health threat.
    • Combination antibiotic therapy is often employed to treat severe S. aureus infections.

    Purpose of the Study:

    • To evaluate the in vitro interaction between vancomycin and rifampin against Staphylococcus aureus.
    • To determine if the combination's efficacy differs between methicillin-susceptible and methicillin-resistant strains.

    Main Methods:

    • The time-kill method was utilized to assess the synergistic, additive, or antagonistic effects of vancomycin and rifampin.
    • Fifty strains of Staphylococcus aureus, encompassing both susceptible and resistant phenotypes, were tested.

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    Main Results:

    • An antagonistic interaction between vancomycin and rifampin was observed in 43 out of 50 tested strains.
    • This antagonism was consistent across both methicillin-susceptible and methicillin-resistant Staphylococcus aureus isolates.

    Conclusions:

    • The combination of vancomycin and rifampin demonstrates antagonism against the majority of Staphylococcus aureus strains tested.
    • These findings suggest caution when using vancomycin and rifampin concurrently for S. aureus infections, irrespective of methicillin resistance status.