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[The vitamin B 12 serum level at various ages]
Folia Haematologica (Leipzig, Germany : 1928)
|January 1, 1977
Summary
Serum vitamin B12 levels naturally decline in healthy adults after age 60. This study analyzed vitamin B12 in 402 individuals, noting lower levels in older women and potential impacts of contraceptives in younger women.
Area of Science:
- Biochemistry
- Gerontology
- Clinical Chemistry
Context:
- Vitamin B12 (cobalamin) is essential for neurological function and DNA synthesis.
- Serum vitamin B12 levels are a key indicator of nutritional status and overall health.
- Age-related changes in vitamin B12 metabolism require further investigation.
Purpose:
- To determine the normal range of serum vitamin B12 in a healthy adult population.
- To investigate the relationship between age and serum vitamin B12 levels.
- To identify potential factors influencing vitamin B12 levels across different age groups.
Summary:
- Radioassay was used to measure serum vitamin B12 in 402 healthy individuals aged 14-98.
- A significant decrease in vitamin B12 was observed in both sexes after age 60.
- Younger women (21-30) showed lower levels, potentially linked to oral contraceptive use.
Impact:
- Establishes normative serum vitamin B12 data across a wide age spectrum.
- Highlights age-dependent physiological changes affecting vitamin B12 status.
- Provides insights into factors influencing vitamin B12 levels, including hormonal influences.