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Radiation and G tolerance in rats

J L Mattsson, R E Cordts, R R Deyak

Aviation, Space, and Environmental Medicine

|July 1, 1981

Summary

Male rats exposed to radiation showed a significant 9.2% decrease in G tolerance, impacting their ability to withstand acceleration stress. Arterial pressure was not significantly affected by the radiation exposure.

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Area of Science:

Aerospace Medicine
Radiation Biology
Physiology

Background:

Understanding the physiological effects of radiation exposure is crucial for spaceflight and high-G environments.
Previous research indicates radiation can impact cardiovascular and physiological responses.

Purpose of the Study:

To investigate the combined effects of radiation exposure and +Gz acceleration on physiological tolerance in male hooded rats.
To assess changes in G tolerance and mean arterial pressure following irradiation.

Main Methods:

Male hooded rats were exposed to 2100 rad of 60Co radiation.
18 hours post-irradiation, rats were subjected to +Gz acceleration until heart rate decreased by 50%.
Carotid mean arterial pressure was measured in a separate, anesthetized group 18 hours post-irradiation.

Main Results:

Irradiated rats exhibited a significant 9.2% reduction in G tolerance compared to control rats (p < 0.05).
Mean arterial pressure in irradiated rats (114.5 torr) was not significantly different from controls (122.1 torr).

Conclusions:

Radiation exposure significantly impairs G tolerance in male hooded rats.
The observed reduction in G tolerance suggests radiation affects the physiological systems responsible for maintaining performance under acceleration stress.
Radiation exposure at this dose did not significantly alter carotid mean arterial pressure.

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