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[Alkylation of 6-benzyl-5H-dibenzo(d,f)-(1,3)diazepine]
Bollettino Della Societa Italiana Di Biologia Sperimentale
|April 15, 1981
Abstract:
The alkylation of 6-benzyl-5H-dibenzo(d,f)-(1,3)diazepine (I) with propyl iodide and dimethylaminopropyl chloride in dimethylformamide solution and in the presence of sodium amide was investigated. In both instances the alkylation affected the methylene of benzyl group instead of the cyclic imino group, however the dimethylaminopropyl derivative does not stand the working up conditions, giving place to 2-amino-2'(alpha-phenyl-delta-dimethylamino)valerylamino-biphenyl (III).