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Related Experiment Videos

Changes in plasma catecholamine concentrations during endotracheal intubation

W J Russell, R G Morris, D B Frewin

    British Journal of Anaesthesia
    |August 1, 1981
    PubMed
    Summary

    Endotracheal intubation significantly increases arterial pressure and plasma noradrenaline levels, indicating a sympathetic nervous system response. Prophylaxis may be needed for at-risk patients during this procedure.

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    Area of Science:

    • Anesthesiology
    • Cardiovascular Physiology
    • Neuroendocrinology

    Background:

    • Endotracheal intubation is a common procedure in critical care and surgery.
    • Hemodynamic and neurochemical responses to intubation can be significant.
    • Understanding these responses is crucial for patient safety.

    Purpose of the Study:

    • To investigate the effects of endotracheal intubation on arterial pressure.
    • To measure changes in arterial concentrations of key catecholamines (noradrenaline, adrenaline, dopamine).
    • To determine the physiological response pattern during intubation.

    Main Methods:

    • Monitoring arterial pressure in 16 patients during endotracheal intubation.
    • Measuring plasma concentrations of noradrenaline, adrenaline, and dopamine.

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  • Analyzing the correlation between hemodynamic changes and catecholamine levels.

    • Main Results:

    • A significant increase in mean arterial pressure was observed post-intubation.
    • Plasma noradrenaline concentrations significantly increased, correlating with elevated arterial pressure.
    • Adrenaline and dopamine levels showed no significant changes following intubation.

    Conclusions:

    • Endotracheal intubation elicits a predominantly sympathetic nervous system response.
    • The observed increase in arterial pressure is closely linked to noradrenaline release.
    • Consideration of prophylactic measures is recommended for patients susceptible to these physiological changes.