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Related Experiment Videos

Erythrocyte deformability in sickle-cell crisis

M W Kenny, M Meakin, D J Worthington

    British Journal of Haematology
    |September 1, 1981
    PubMed
    Summary

    Erythrocyte deformability decreases early in sickle-cell crisis, preceding viscosity changes. Measuring erythrocyte filterability aids understanding early sickle-cell crisis pathogenesis.

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    Area of Science:

    • Hematology
    • Rheology
    • Sickle Cell Disease Research

    Background:

    • Sickle-cell vaso-occlusive crisis involves complex rheological changes.
    • Understanding early events in crisis is crucial for effective management.

    Purpose of the Study:

    • To investigate serial changes in erythrocyte deformability, plasma viscosity, and whole-blood viscosity during sickle-cell vaso-occlusive crises.
    • To compare rheological parameters during crisis with asymptomatic states.

    Main Methods:

    • Serial measurements of erythrocyte deformability using filtration through polycarbonate filters.
    • Assessment of plasma and whole-blood viscosity.
    • Confirmation of crisis duration using peak serum lactate dehydrogenase levels.

    Main Results:

    • Erythrocyte deformability significantly reduced by day 1 of crisis, sometimes preceding pain onset.
    • No significant increase in irreversibly-sickled cells observed.
    • Plasma and blood viscosity increased significantly around day 5, correlating with fibrinogen levels.

    Conclusions:

    • Reduced erythrocyte filterability is an early indicator of sickle-cell crisis.
    • Erythrocyte filterability is a valuable tool for studying early sickle-cell crisis pathogenesis.
    • Viscosity changes occur later in the crisis progression compared to deformability changes.

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