A new metabolite of propachlor isolated from germfree rat excreta

2-[S-(N-Acetyl)cysteine]-isopropylacetanilide sulfoxide was isolated from the excreta of germfree rats given oral doses of 2-chloro-N-isopropylacetanilide. The metabolite was characterized by mass and nuclear magnetic resonance spectrometry on samples isolated from rats dosed with [1-14C]-and [2-13C]-2-chloro-N-iso-propylacetanilide. Artifact formation upon reaction of the sulfoxide with alcoholic HCl is discussed.