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[Correction of hypersensitivity to strophanthin in experimental myocardial infarction by pharmacologic effects on
Biulleten' Eksperimental'Noi Biologii I Meditsiny
|June 1, 1981
Abstract:
Experiments on 176 cats with experimental myocardial infarction were made to study alterations in ouabain tolerance under pharmacological effects on extracardial innervation. It was shown that elimination of sympathetic innervation at different levels by benzohexonium, ornid and anapriline, as well as its relative weakening by proserine favoured the correction of hypersensitivity to ouabain in acute myocardial ischemia. Potentiation of sympatic effects by ephedrine and abolition of parasympathetic innervation by atropine increased ouabain cardiotoxicity.