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Morphine-theophylline interaction: antagonism or facilitation?

S Brailowsky, F Guerrero-Muñoz, M Luján

    British Journal of Pharmacology
    |August 1, 1981
    PubMed
    Summary

    Theophylline modifies morphine

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    Area of Science:

    • Pharmacology
    • Neuroscience

    Background:

    • Morphine is a potent opioid analgesic.
    • Theophylline is a methylxanthine drug.
    • Interactions between opioids and methylxanthines require further investigation.

    Purpose of the Study:

    • To investigate the interactions between morphine and theophylline.
    • To examine these interactions in both acute and narcotic-dependent states.
    • To utilize diverse experimental models for comprehensive analysis.

    Main Methods:

    • Acute and chronic opioid-dependent animal models (mice, guinea-pigs).
    • In vitro and in vivo experimental designs.
    • LD50 determination, isolated ileum preparations, jump tests, and synaptosomal calcium uptake assays.

    Main Results:

    • Theophylline significantly increased the LD50 of morphine.
    • Theophylline demonstrated protective effects against morphine inhibition and naloxone-induced withdrawal.
    • Theophylline reduced naloxone-induced jumps and morphine's inhibition of calcium uptake.

    Conclusions:

    • Theophylline modulates morphine's effects, including its lethality and inhibitory actions.
    • Theophylline exhibits antagonistic properties against opioid withdrawal symptoms.
    • Calcium signaling may play a role in the observed morphine-theophylline interactions.

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