Clastogenic activity of dried fruits

The clastogenic activities of several commercially-dried fruits, including black and golden-seedless raisins, medium-sized California prunes, table dates, bananas, California black mission figs and breakfast apricots, were examined using Chinese hamster ovary (CHO) cells as the test organism and chromosome aberrations as the endpoint. Treatment of the CHO cells with water extracts of these dried fruits significantly increased the frequencies of metaphase plates with 1 chromosome break or exchange as well as the average number of chromosome exchanges per metaphase plate. A liver microsomal S9 mixture reduced this clastogenic activity. Dried fruits represent an example of widely consumed food products with strong genotoxic activities.