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Left ventricular function in patients with chronic obstructive pulmonary disease

G Louridas, D Patakas, C Stavropoulos

    Cardiology
    |January 1, 1981
    PubMed
    Summary
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    Severe chronic obstructive pulmonary disease (COPD) can alter left ventricular systolic time intervals due to increased right ventricular afterload. However, direct left ventricular function remains normal in most COPD patients.

    Area of Science:

    • Cardiology
    • Pulmonology
    • Medical Physiology

    Background:

    • Severe chronic obstructive pulmonary disease (COPD) significantly impacts cardiopulmonary function.
    • Understanding the effects of COPD on left ventricular (LV) function is crucial for patient management.

    Purpose of the Study:

    • To evaluate left ventricular (LV) systolic function in patients with severe COPD.
    • To investigate the relationship between pulmonary hypertension and LV performance in COPD.

    Main Methods:

    • Assessed 24 severe COPD patients and 21 healthy controls.
    • Measured left ventricular systolic time intervals (STI) and echocardiographic parameters (ejection fraction, Vcf).
    • Recorded pulmonary artery pressures in a subset of COPD patients.

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    Main Results:

    • Patients with severe COPD exhibited abnormal left ventricular systolic time intervals (STI).
    • Echocardiographic parameters and pulmonary wedge pressure were generally normal.
    • One patient showed high pulmonary arterial wedge pressure and low Vcf; two had ejection fraction <60%.

    Conclusions:

    • Abnormal left ventricular STI in COPD is likely due to increased right ventricular afterload and inter-ventricular interaction.
    • Direct left ventricular systolic function is preserved in most patients with severe COPD.