Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Digoxin-verapamil interaction

K E Pedersen, A Dorph-Pedersen, S Hvidt

    Clinical Pharmacology and Therapeutics
    |September 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The metabolism and pharmacokinetics of isotretinoin in patients with acne and rosacea are not influenced by ethanol.

    The British journal of dermatology·2009
    Same author

    The long-term pharmacokinetics and safety of adding low-dose ritonavir to a nelfinavir 1,250 mg twice-daily regimen in HIV-infected patients.

    HIV medicine·2005
    Same author

    Drugs in injured drivers in Denmark.

    Forensic science international·2005
    Same author

    Pharmacokinetic interaction between rifampin and the combination of indinavir and low-dose ritonavir in HIV-infected patients.

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2004
    Same author

    Systemic levels of cotinine and elastase, but not pulmonary function, are associated with the progression of small abdominal aortic aneurysms.

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2003
    Same author

    Continued improvement of clinical outcome and cost effectiveness following intravascular ultrasound guided PCI: insights from a prospective, randomised study.

    Heart (British Cardiac Society)·2003

    Verapamil significantly alters digoxin pharmacokinetics in healthy subjects. This drug interaction increases digoxin

    Area of Science:

    • Pharmacology
    • Clinical Pharmacology
    • Drug Interactions

    Background:

    • Digoxin is a cardiac glycoside used to treat heart failure and arrhythmias.
    • Verapamil is a calcium channel blocker used to treat hypertension and angina.
    • Potential interactions between digoxin and verapamil require investigation.

    Purpose of the Study:

    • To investigate the pharmacokinetic interaction between digoxin and verapamil.
    • To determine how verapamil treatment affects digoxin's absorption, distribution, metabolism, and excretion.

    Main Methods:

    • A single-dose pharmacokinetic study of digoxin was conducted in eight healthy subjects.
    • The study was repeated after 10 days of verapamil treatment.
    • Key pharmacokinetic parameters including volume of distribution, clearance, and half-life were analyzed.

    Related Experiment Videos

    Main Results:

    • Verapamil significantly reduced the apparent central distribution volume of digoxin (P < 0.05).
    • Total body clearance of digoxin was reduced by verapamil, affecting both renal and extrarenal clearance (P < 0.001).
    • The biological half-life of digoxin increased significantly (P < 0.005).

    Conclusions:

    • Verapamil impairs both renal and extrarenal clearance of digoxin, potentially by inhibiting tubular secretion.
    • The exact mechanisms for the extrarenal interaction are unknown but may involve impaired hepatic degradation.
    • Clinicians should consider this interaction when co-prescribing digoxin and verapamil.