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Related Experiment Videos

Recent research on nickel carcinogenesis

F W Sunderman

    Environmental Health Perspectives
    |August 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Workers in nickel refineries face higher risks of nasal and lung cancers, supported by epidemiological and carcinogenicity studies. Research also explored nickel compound effects on cellular DNA and bacterial mutagenicity.

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    Area of Science:

    • Environmental Health
    • Toxicology
    • Oncology

    Background:

    • Occupational exposure to nickel compounds is a recognized health concern.
    • Previous research indicated potential links between nickel exposure and cancer.
    • Understanding nickel's carcinogenic mechanisms is crucial for worker safety.

    Purpose of the Study:

    • To review and synthesize research on nickel carcinogenesis from 1975 to March 1980.
    • To evaluate epidemiological evidence linking nickel refinery work to cancer risk.
    • To investigate the biological mechanisms of nickel-induced carcinogenicity.

    Main Methods:

    • Review of epidemiological studies on nickel refinery workers.
    • Analysis of carcinogenicity tests in animal models (rodents).

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  • In vitro studies on mammalian cells and bacterial mutagenicity assays.

    • Main Results:

    • Epidemiological data show increased lung and nasal cavity cancer risks in nickel refinery workers.
    • Nickel subsulfide (alpha-Ni3S2) demonstrated carcinogenicity in rodents via parenteral routes.
    • In vitro studies indicated nickel compounds induce chromosomal aberrations and somatic mutations, but bacterial mutagenicity tests were negative.
    • Nickel(II) impaired DNA polymerase fidelity in vitro.

    Conclusions:

    • Evidence strongly links nickel refinery work to increased respiratory cancer risk.
    • Nickel subsulfide is a confirmed carcinogen in animal models.
    • Nickel compounds exhibit genotoxic effects in mammalian cells but not in bacteria, suggesting complex carcinogenic pathways.