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Generalized acanthosis nigricans

V C Andreev, L Boyanov, N Tsankov

    Dermatologica
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    A patient with advanced gastric cancer developed a widespread skin condition including acanthosis nigricans and the sign of Leser-Trélat. This paraneoplastic syndrome may be caused by tumor-secreted growth factors.

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    Area of Science:

    • Dermatology
    • Oncology
    • Pathology

    Background:

    • Gastric carcinoma is a significant global health concern.
    • Paraneoplastic syndromes can manifest with diverse cutaneous findings.
    • The sign of Leser-Trélat is a rare dermatological sign associated with internal malignancy.

    Observation:

    • A patient with advanced, inoperable gastric carcinoma presented with a severe, generalized paraneoplastic syndrome.
    • The syndrome included intense pruritus, acanthosis nigricans, sign of Leser-Trélat (seborrheic keratoses and freckles), warty excrescences, palmoplantar hyperkeratosis, and oral mucosal lesions.
    • The entire skin surface was affected, suggesting a generalized form of acanthosis nigricans.

    Findings:

    • The observed clinical presentation was consistent with generalized acanthosis nigricans.

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  • The authors propose a tumor-derived growth-stimulating factor as a potential cause for this paraneoplastic syndrome.
  • The association between acanthosis nigricans and the sign of Leser-Trélat in this context is discussed.

    • Implications:

    • This case highlights the potential for extensive skin manifestations in advanced gastric cancer.
    • Understanding the link between gastric carcinoma and paraneoplastic syndromes like acanthosis nigricans is crucial for diagnosis and management.
    • Further research into tumor-secreted factors may offer insights into novel therapeutic targets.