[Interaction problems in the therapy with steroid-free anti-rheumatics]

In a review the known interactions between non-steroidal antirheumatic drugs and others are summarized. Of clinical importance are interactions with digitalis, anticoagulants, oral antidiabetics, beta receptor antagonists, antihypertensive drugs, and diuretics. Interactions may occur if uricosurics or anticonvulsive drugs are administered together with non-steroidal antirheumatic drugs. Interactions are observed between different antirheumatic drugs when administered together. Undesirable side effects induced by drug interactions can be avoided by means of administration of suitable drugs in those cases in which a combined treatment is necessary.