Dexamethasone treatment during hemorrhagic shock: effects independent of increased blood pressure

Effects of dexamethasone (5 mg/kg of body weight) on organ blood flow, enzyme release, and hemodynamics were studied in dogs with hemorrhagic shock to determine if the consequences observed were due to increased mean arterial blood pressure (MABP) or intrinsic effects of dexamethasone. Hemorrhage was induced in anesthetized dogs until the MABP was 50 mm of Hg and then the dogs were treated with dexamethasone or an equal volume of saline solution. Dogs remained connected to the blood reservoir during the entire experiment and MABP was maintained at 50 mm of Hg in the treated and control groups of dogs. Beneficial actions of dexamethasone treatment independent of increased MABP were observed. Increased survival rate, differential blood flow to some organs, and less tissue damage occurred as a result of dexamethasone treatment and were independent of increased MABP.