Mass spectral quantitation of cocaine HCl in powders

Gas-liquid chromatography (GLC) using a mass spectrometer (MS) as a detector is used for the quantitative determination of cocaine HCl in powders. After the sample is dissolved in methanol containing deuterated cocaine HCl internal standard, an aliquot is injected into the GLC-MS system with the mass spectrometer operating in the scan mode. The cocaine HCl concentration is calculated from the 303/308 m/e ratio. The procedure has a relative deviation of approximately 2.3% and is applicable to samples containing a wide variety of diluents and adulterants.