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Abnormal thyroid stimulating hormone following pituitary surgery

G K Worth, R W Retallack, D H Gutteridge

    Journal of Endocrinological Investigation
    |April 1, 1981
    PubMed
    Summary
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    This study reports the first case of abnormal, but biologically inactive thyroid stimulating hormone (TSH) in a euthyroid patient after pituitary surgery. This finding suggests TSH abnormalities can occur even without hypothyroidism.

    Area of Science:

    • Endocrinology
    • Molecular Biology
    • Pituitary Gland Research

    Background:

    • Thyroid stimulating hormone (TSH) is crucial for thyroid function.
    • Biologically inactive TSH has been previously observed in hypothyroid patients.
    • Pituitary adenomas can necessitate surgical intervention, potentially affecting hormone production.

    Observation:

    • A patient, euthyroid after hypophysectomy for a prolactinoma, exhibited immunoreactive TSH.
    • This TSH was found to be biologically inactive.
    • Gel chromatography revealed an approximate molecular weight of 23,000 daltons for the abnormal TSH.

    Findings:

    • This is the first reported case of abnormal, immunoreactive TSH in a euthyroid patient post-hypophysectomy.
    • The abnormal TSH demonstrated biological inactivity, despite being detectable by immunoassay.

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  • The characterized TSH molecule had a reduced molecular weight.

    • Implications:

    • Abnormal TSH variants may exist in euthyroid individuals, challenging standard diagnostic interpretations.
    • This case highlights the potential for altered TSH structure and function after pituitary surgery.
    • Further research is needed to understand the clinical significance and prevalence of biologically inactive TSH variants.