Related Experiment Video
Updated: Aug 18, 2026

A Simple Composite Phenotype Scoring System for Evaluating Mouse Models of Cerebellar Ataxia
Published on: May 21, 2010
Linkage investigations in two families with hereditary ataxia
Abstract:
In two families with autosomal dominant olivopontocerebellar atrophy (type IV), 15 affected and 44 unaffected members were typed for 28 genetic markers, including HLA. The lod scores for a possible HLA linkage, plotted against recombination fractions from 0.01 to 0.4, were negative. No evidence emerged for the presence of the ataxia-locus within measurable distance of the HLA-loci on chromosome 6. No indications were obtained that the ataxia-gene is linked with one of the other marker-genes.
Related Concept Videos
Genetic Lingo
Dihybrid Crosses
Pedigree Analysis
Sex-linked Disorders
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Huntington Disease l: Introduction

