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Updated: Aug 17, 2026

An Ivor Lewis Esophagectomy Designed to Minimize Anastomotic Complications and Optimize Conduit Function
Published on: April 17, 2020
Infants with esophageal atresia weighing under 3 pounds
Insights
Even the smallest infants with esophageal atresia can survive with proper care. Advances in preoperative, operative, and postoperative management have significantly improved survival rates for low birth weight infants.
Area of Science:
- Pediatric Surgery
- Neonatal Care
- Congenital Malformations
Background:
- Esophageal atresia (EA) presents significant challenges in neonates, particularly those with low birth weight.
- Historically, infants weighing under 3 lb (1360 g) had a poor prognosis.
Purpose of the Study:
- To evaluate the survival rates and outcomes of low birth weight infants undergoing surgery for EA.
- To identify factors influencing survival and propose improved management strategies.
Main Methods:
- Retrospective analysis of 339 infants with EA treated between 1953 and the study period.
- Detailed review of preoperative, operative, and postoperative management, including transport and intensive care.
- Analysis of surgical techniques and their impact on outcomes.
Main Results:
- Only 12 (4%) infants weighed under 3 lb at operation.
- Before 1957, all infants under 3 lb died; after 1957, five of six infants (between 2-3 lb) survived.
- The single fatality in the later group was due to an inappropriate surgical approach.
Conclusions:
- With meticulous preoperative, operative, and postoperative care, even the smallest infants with EA can survive.
- Associated malformations, particularly cardiac and neurological, are now the primary determinants of mortality.
- Infants with extremely low birth weights should achieve normal development following successful EA repair.
Abstract:
In a consecutive series of 339 infants with esophageal atresia seen since 1953 first in Liverpool and subsequently in Zurich, 12 or 4% weighed under 3 lb (1360 g) at the time of operation. Four had severe additional malformations causing death in the immediate postoperative period. Before 1957, all the infants weighing under 3 lb died, but of the six infants weighing between 2 and 3 lb (910 and 1360 g) operated upon by the author since that time, five have recovered. The only fatality was caused by the wrong choice of operation. This is discussed in detail. There appear to be no reasons why even the smallest infant with esophageal atresia should not survive, provided certain precautions in the preoperative, operative, and postoperative management are taken. These special methods are discussed in detail with special reference to transport, intensive therapy management, and operative technique. Follow-up examinations of these infants show that their subsequent development has been perfectly normal. On the basis of these figures it is suggested that today, associated malformations, especially of the heart and brain, are the only causes of postoperative mortality in esophageal atresia and that infants with even extremely low birth weights should survive.
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