Induction of constant sensitivity to dinitrochlorobenzene in the cynomolgus monkey

A technique for the induction of contact sensitivity in the cynomolgus monkey is described. Seventy percent of the monkeys gave a positive reaction when skin-tested 18 days after sensitization with dinitrochlorobenzene. When re-tested on day 27, both the number of reactors and the intensity of the reactions had increased. Histological examinations showed perivascular leukocytic infiltration with an increased proportion of mononuclear cells, typical of a delayed hypersensitive reaction.