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Drugs--some basic concepts

G D Sweeney

    Medicine and Science in Sports and Exercise
    |January 1, 1981
    PubMed
    Summary

    People with chronic health conditions are exercising more while on medication. This review explores how exercise impacts drug metabolism and performance, applying core principles of pharmacokinetics and pharmacodynamics.

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    Area of Science:

    • Pharmacology
    • Exercise Physiology
    • Clinical Medicine

    Background:

    • Growing trend of individuals with chronic health conditions (cardiac, pulmonary, renal, musculoskeletal, behavioral) adopting active lifestyles.
    • Limited understanding of the bidirectional interactions between exercise and drug action.
    • Need to explore how physical activity influences drug metabolism and how medications affect exercise capacity.

    Purpose of the Study:

    • To review fundamental concepts of pharmacokinetics and pharmacodynamics.
    • To discuss the implications of these principles in the context of exercise.
    • To highlight the importance of understanding drug-exercise interactions for patient care.

    Main Methods:

    • Review of basic principles of pharmacokinetics (drug concentration determinants).
    • Review of basic principles of pharmacodynamics (drug biological effects).
    • Application of these principles to the context of exercise and medication.

    Main Results:

    • Pharmacokinetic processes (absorption, distribution, metabolism, excretion) can be influenced by exercise intensity and duration.
    • Pharmacodynamic effects of drugs may be altered during physical activity.
    • While specific data is scarce, established pharmacological principles offer a framework for understanding these interactions.

    Conclusions:

    • Exercise can significantly alter drug pharmacokinetics and pharmacodynamics.
    • Understanding these interactions is crucial for optimizing treatment and ensuring safety in active patients.
    • Further research is needed to elucidate specific drug-exercise relationships across various conditions and medications.

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