[Effect of morphine on dialyzed Helix pomatia neurons]

Intra- and extracellular influence of morphine was studied on isolated snail neurons by the method of intracellular dialysis under conditions of membrane potential clamp. It is found that morphine induces an inward current in all the investigated cells, it also changes the sensitiveness of the membrane to acetylcholine depending on the type of cell under investigation. It is suggested that such influence in normally functioning cells may be realized by endogenic peptides-analgetics.