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Bilateral asymmetry in brain GABA function?

M S Starr, I C Kilpatrick

    Neuroscience Letters
    |September 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Researchers investigated the brain

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    Area of Science:

    • Neuroscience
    • Biochemistry

    Background:

    • The gamma-aminobutyric acid (GABA) system is the primary inhibitory neurotransmitter system in the mammalian brain.
    • Understanding GABAergic neurotransmission is crucial for comprehending brain function and neurological disorders.

    Purpose of the Study:

    • To investigate the regional distribution and asymmetry of GABAergic system components in the rat brain.
    • To examine the effects of inhibiting GABA catabolism on GABA levels and enzyme activities.

    Main Methods:

    • Inhibition of GABA catabolism using intracisternal ethanolamine-O-sulphate and intraperitoneal aminooxyacetic acid in rats.
    • Measurement of GABA aminotransferase and glutamate decarboxylase activities.
    • Quantification of GABA content in various brain regions.

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    Main Results:

    • Both tested inhibitors reduced GABA aminotransferase and glutamate decarboxylase activities uniformly across brain nuclei.
    • GABA levels showed significant, region-specific lateralization, with higher concentrations in distinct areas of the right and left hemispheres.
    • No significant bilateral asymmetry in GABA content was observed in the globus pallidus.

    Conclusions:

    • The study reveals inherent functional inequalities in GABAergic systems between the left and right hemispheres of the rat brain.
    • These findings suggest a complex, asymmetric regulation of GABAergic neurotransmission with potential implications for brain lateralization and function.