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Opiate pharmacology and individual differences. II. Somatosensory evoked potentials
Monte S Buchsbaum1, Glenn C Davis, Richard Coppola
1Section on Clinical Psychophysiology, National Institute of Mental Health, Clinical Center, Room 2N212, Bethesda, Md. 20205, USA University of Tennessee, Center for the Health Sciences, Memphis, Tenn. 38105, USA Laboratory of Psychology and Psychopathology, National Institute of Mental Health, Clinical Center, Room 2N218, Bethesda, Md. 20205, U.S.A. Psychiatrische Universitaetsklinik, Nussbaumstr. 7, D-8000 Munich, G.F.R.
Abstract:
Somatosensory evoked potentials (EPs) to stimuli ranging from barely perceptible to painful were recorded in 153 normal adults. Reliability of amplitude and amplitude/intensity slopes were demonstrated in 29 individuals tested twice, two or more weeks apart. In randomized, double-blind placebo controlled trials, both aspirin and morphine significantly diminished N120 component at high stimulus intensities. Age, sex and pharmacological effects paralleled those found with psychophysical techniques in part I of this study.