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Related Experiment Videos

Copper deficiency with cow's milk diet

Y Naveh, A Hazani, M Berant

    Pediatrics
    |September 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Unrecognized copper deficiency can cause severe anemia and neutropenia in infants. Prompt copper supplementation effectively treated these conditions, highlighting the importance of serum copper testing.

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    Area of Science:

    • Pediatric Hematology
    • Nutritional Science
    • Biochemistry

    Background:

    • Infants fed exclusively cow's milk and corn flour are at risk for nutritional deficiencies.
    • Severe anemia and neutropenia in infants necessitate a thorough diagnostic workup.

    Observation:

    • A 6-month-old infant presented with severe anemia and neutropenia, unresponsive to standard iron, folic acid, and vitamin C therapy.
    • Investigations revealed hypocupremia, low ceruloplasmin, bone abnormalities, and vacuolization in hematopoietic precursors with ringed sideroblasts.

    Findings:

    • Copper sulfate administration led to a rapid increase in neutrophils and reticulocytes.
    • The infant achieved and maintained normal hematological parameters, including hemoglobin and neutrophil counts, one year after copper therapy cessation.

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    Implications:

    • This case highlights the critical role of copper in infant hematopoiesis and immune function.
    • Serum copper levels should be considered in infants presenting with refractory anemia and neutropenia, especially those with suboptimal diets.
    • Early diagnosis and treatment of copper deficiency are crucial for preventing severe hematological complications in infants.