Some pharmacological effects of 17(S) methyl-omega-homo-trans-delta2-PGE1 (ONO 1206)

17(s) methyl-omega-homo-trans-delta2-PGE1 (ONO 1206) produced qualitatively similar effects to PGE1 in several systems. It was 18.4 and 25.6 times respectively more potent than PGE1 in inhibiting ADP-induced baboon and human platelet aggregation in vitro. Intravenous infusion of ONO 1206 in baboon also produced ex-vivo inhibition of ADP-induced platelet aggregation. However, this was accompanied by a significant fall in blood pressure and an increase in heart rate. The potent relaxant effect of ONO 1206 on human respiratory tract smooth muscle in vitro suggests that this compound may be a bronchodilator in man.