Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sulfhydryl compounds may mediate gastric cytoprotection

S Szabo, J S Trier, P W Frankel

    Science (New York, N.Y.)
    |October 9, 1981
    PubMed
    Summary

    Ethanol causes gastric erosions by decreasing sulfhydryl compounds. Sulfhydryl drugs may protect against these erosions, suggesting a role for sulfhydryls in gastric cytoprotection.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Antibodies to intestinal microvillous membranes : ii. Inhibition of intrinsic factor-mediated attachment of vitamin b(12)to hamster brush borders.

    The Journal of experimental medicine·2009
    Same author

    Myocardial troponin T release is associated with enhanced fibrinolysis in patients with acute coronary syndromes.

    Thrombosis and haemostasis·2002
    Same author

    The effects of an HIV-1 immunogen (Remune) on viral load, CD4 cell counts and HIV-specific immunity in a double-blind, randomized, adjuvant-controlled subset study in HIV infected subjects regardless of concomitant antiviral drugs.

    HIV medicine·2001
    Same author

    Aortic valve endocarditis with paravalvular abscesses caused by Erysipelothrix rhusiopathiae.

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2001
    Same author

    Gene expression and gene therapy in experimental duodenal ulceration.

    Journal of physiology, Paris·2001
    Same author

    The thrombolytic paradox.

    Thrombosis research·2001

    Area of Science:

    • Gastroenterology
    • Pharmacology
    • Biochemistry

    Background:

    • Ethanol is a known cause of gastric mucosal damage.
    • Nonprotein sulfhydryl compounds are present in gastric mucosa.
    • Prostaglandins play a role in protecting the gastric lining.

    Purpose of the Study:

    • To investigate the role of nonprotein sulfhydryl compounds in ethanol-induced gastric erosions.
    • To explore the potential cytoprotective effects of sulfhydryl-containing drugs.

    Main Methods:

    • Rats were administered ethanol to induce gastric erosions.
    • Concentrations of nonprotein sulfhydryl compounds in gastric mucosa were measured.
    • The effects of sulfhydryl-containing drugs and blocking agents on gastric erosions and prostaglandin activity were assessed.

    Main Results:

    • Ethanol induced dose-dependent hemorrhagic gastric erosions.
    • Ethanol decreased nonprotein sulfhydryl concentrations in the gastric mucosa.
    • Sulfhydryl-containing drugs offered protection against ethanol-induced erosions.
    • Sulfhydryl blocking agents diminished the cytoprotective effect of prostaglandin F2 beta.

    Conclusions:

    • Endogenous nonprotein sulfhydryls may mediate prostaglandin-induced gastric cytoprotection.
    • Sulfhydryl-containing drugs show potential for preventing and treating hemorrhagic gastric erosions.

    Related Experiment Videos