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Related Experiment Videos

Hypothyroid myopathy in two dogs

K G Braund, A R Dillon, J R August

    Veterinary Pathology
    |September 1, 1981
    PubMed
    Summary

    Primary hypothyroidism in dogs causes skeletal muscle changes, specifically affecting type II muscle fibers. These findings suggest a metabolic defect in these fibers, even without clinical signs of neuromuscular disease.

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    Area of Science:

    • Veterinary Pathology
    • Canine Endocrinology
    • Muscle Physiology

    Background:

    • Primary hypothyroidism is common in dogs.
    • Neuromuscular complications are not typically associated with canine hypothyroidism.
    • Skeletal muscle and peripheral nerve tissues were examined in hypothyroid dogs.

    Purpose of the Study:

    • To investigate potential subclinical muscle and nerve changes in dogs with primary hypothyroidism.
    • To determine if hypothyroidism affects skeletal muscle fiber types differently.
    • To explore the underlying pathophysiology of muscle alterations in hypothyroid dogs.

    Main Methods:

    • Histological, histochemical, and morphometric analyses were performed on skeletal muscle and peripheral nerve biopsies.
    • Muscle fiber size variation and type II fiber diameter were quantified.
    • Nerve tissues were compared to age-matched controls.

    Main Results:

    • Skeletal muscle showed significant variation in fiber size.
    • A pronounced reduction in the mean diameter of type II muscle fibers was observed.
    • Type II fiber loss was noted in one of the two dogs studied.
    • No significant histological or morphometric differences were found in peripheral nerves.

    Conclusions:

    • Hypothyroidism in dogs is associated with myopathic changes, particularly affecting type II muscle fibers.
    • These findings suggest a preferential metabolic defect in type II fibers.
    • Subclinical muscle alterations can occur in dogs with hypothyroidism, even without overt neuromuscular disease.

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