[The hemodynamic profile of pentaerythrityl tetranitrate]

On altogether 17 patients with different stages of the chronic ischaemic heart disease before and after oral application of 20 and 40 mg PETN in form of Pentalong HR, AP, PAEDP and CO were measured. According to this PETN proves to be haemodynamically active, since in the optimum of the effect it reduces the PAEDP independent on the initial pressure by on an average 30-40%. The beginning of the effect lies between 30 and 45 min. The duration of the effect is prolonged, when 40 mg are used. A consequent nitrotherapy with PETN demands 4-6 times 40 mg, in these cases remains without any side-effects and is indicated in accumulated angina pectoris for smoothing the course of PAEDP, in angina pectoris with latent or manifest left heart insufficiency and in increase of the filling pressure after acute myocardial infarction.