[Comparative biochemical studies in asymptomatic hyperuricemia and manifest gout with special reference to renal...

It is reported on results of comparative biochemical examinations in asymptomatic hyperuricaemia and manifest gout. Restriction of the urate clearance of the kidney, which could be proved also in young patients with asymptomatic hyperuricaemia, and a disturbance of the lipid metabolism which appeared in most cases are discussed from the pathogenetic point of view, in which cases the hyperlipoproteinaemia is regarded as a possible partial pathogenetic factor. For the separation of serum and urine the polyacrylamide gel-pore gradient electrophoresis was used. Using a modifiable concentration gradient this method is superior to the usual disc electrophoresis. The distribution pattern of the types of haptoglobin established by serum separation showed clear deviations from the normal distribution in hyperuricaemia or manifest gout and may be explained as a reference to the influence of genetic factors. By parallel performed electrophoretic separation of serum and urine a microproteinuria could be established and differentiated between glomerular and tubular proteinuria which is regarded as an early symptom of renal changes and was already present in 9 of 20 young patients with asymptomatic hyperuricaemia. These findings emphasize the necessity of an early renal diagnostics.