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[Blood coagulation in hyperthermia]

W D Zwierzina, M Herold, R Günther

    Zeitschrift Fur Rheumatologie
    |November 1, 1980
    PubMed
    Summary

    Physical hyperthermia, like hot baths, may increase the risk of thrombosis by altering blood coagulation. This study found changes in fibrinogen and other factors after hot baths, suggesting a pro-thrombotic tendency.

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    Area of Science:

    • Physiology
    • Hematology
    • Rheumatology

    Background:

    • Physical hyperthermia (baths) are used in treating rheumatic diseases.
    • Understanding the effects of hyperthermia on blood coagulation is crucial for patient safety.

    Purpose of the Study:

    • To investigate the impact of physical hyperthermia on blood coagulation and fibrinolysis in healthy volunteers.
    • To assess potential thrombotic risks associated with hot bath therapy.

    Main Methods:

    • Healthy volunteers underwent single hot baths, reaching mean body temperatures between 38.2-39.9°C.
    • Blood samples were analyzed for changes in coagulation factors, fibrinogen, plasminogen, and thrombelastogram parameters.
    • A series of hypothermic baths were also administered to observe their effects.

    Main Results:

    • Hot baths led to increased levels of fibrinogen, coagulation factors IX and XII, and hemoglobin.
    • Maximal amplitude of the thrombelastogram (a measure of clot strength) also increased.
    • A decrease in plasminogen levels was observed post-hyperthermia.
    • Hypothermic baths did not induce significant changes in coagulation or fibrinolysis.

    Conclusions:

    • Hyperthermia, induced by hot baths, appears to promote a pro-thrombotic state.
    • The observed changes in coagulation parameters suggest an increased tendency towards thrombosis.
    • Further research is needed to clarify the clinical implications for patients undergoing hyperthermia treatment.

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