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Systemic lupus erythematosus and pulmonary hypertension
Zeitschrift Fur Rheumatologie
|May 1, 1981
Summary
Systemic lupus erythematosus (SLE) can cause pulmonary hypertension. Treatment with steroids, cytotoxic drugs, and anticoagulants improved symptoms and pulmonary changes in three patients with SLE.
Area of Science:
- Rheumatology
- Pulmonology
- Internal Medicine
Background:
- Pulmonary hypertension is a known complication of Systemic Lupus Erythematosus (SLE).
- SLE pulmonary manifestations can present with diverse clinical and radiological findings.
Observation:
- Three patients with SLE developed pulmonary hypertension, with varied onset and initial presentation.
- Symptoms included dyspnea and chest pain, with lung function studies revealing restrictive changes.
Findings:
- Lung biopsy showed interstitial fibrosis, inflammation, and vascular changes.
- Treatment with steroids, cytotoxic drugs, and anticoagulants led to improved pulmonary hypertension and reduced symptoms.
Implications:
- Early recognition and treatment of pulmonary hypertension in SLE patients are crucial.
- Aggressive management can lead to significant clinical and radiological improvement.