Enzyme inducer effects after liver denervation in the rat

The part of liver innervation was studied in the process of microsomal enzyme induction elicited by phenobarbital or muscular exercise. Enzyme induction was seen to develop: hexobarbital sleeping times became shorter after partial (vagotomy, coeliectomy) as well as total liver denervation in the rat. Though the present results did not preclude subtile differences, they demonstrated that the microsomal enzyme systems of the liver could be activated in the absence of innervation. Upper median laparatomy, which was used as a sham operation, had the strange effect of elongating the sleeping time. This observation is a warning of a changed rate of drug elimination after explorative laparatomy.