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Related Experiment Videos

Arterial baroreceptor reflex function during elevation on intracranial pressure

R A Little, B Oberg

    Acta Physiologica Scandinavica
    |May 1, 1981
    PubMed
    Summary

    The arterial baroreceptor reflex poorly buffers blood pressure changes from increased intracranial pressure (ICP). Even with high baroreceptor activity, the reflex cannot fully restore normal blood pressure levels during elevated ICP.

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    Area of Science:

    • Cardiovascular Physiology
    • Neuroscience

    Background:

    • The arterial baroreceptor reflex is a key regulator of blood pressure.
    • Elevated intracranial pressure (ICP) can significantly impact cardiovascular function.
    • Understanding the interplay between ICP and baroreflex is crucial for managing neurological conditions.

    Purpose of the Study:

    • To investigate the capacity of the arterial baroreceptor reflex to buffer blood pressure responses during elevated intracranial pressure (ICP).

    Main Methods:

    • Experiments were conducted on chloralose-anesthetized cats.
    • Intracranial pressure (ICP) was systematically increased.
    • Blood pressure responses and baroreceptor activity were monitored.

    Main Results:

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    • Elevated ICP consistently produced pressor responses of similar magnitude, regardless of baroreceptor activity levels.
    • Baroreceptor activation during elevated ICP led to reflex reductions in blood pressure and flow resistance, but not to baseline levels.
    • An upward shift in the pressure-response curve of the carotid sinus was observed when ICP was elevated.

    Conclusions:

    • The arterial baroreceptor reflex's ability to buffer blood pressure is impaired during elevated intracranial pressure.
    • The reflex's effectiveness in counteracting ICP-induced hypertension is limited, suggesting a potential disruption in cardiovascular regulation under these conditions.