Related Experiment Videos
Rise of blood pressure in calcium-deprived pregnant rats
It has been postulated that calcium uptake is inversely related to blood pressure (BP) in animals and pregnant women. To test this hypothesis, 34 female, 142-day-old Wistar rats were studied prospectively. They were randomly assigned to either a calcium-free diet (16 rats) or a normal diet (18 rats). Weekly measurements of tail systolic BP showed a statistically significant increase in BP in the calcium-free group after 6 weeks of treatment. After 9 weeks on this diet, the animals were mated. Five in the control group and six in the calcium-free group became pregnant. Thereafter, both of these subgroups (pregnant and nonpregnant calcium-free diet) continued with significantly higher BP until they were put to death. Blood samples taken at the end of the study showed significantly lower values of calcium/magnesium (Ca/Mg) ratio, but higher inorganic phosphate in the group consuming a calcium-free diet. Blood pressure during the last 3 weeks of the study was significantly inversely correlated with the blood Ca/Mg ratio and directly correlated with magnesium and inorganic phosphate values. This article supports the hypothesis that a low-calcium diet is associated with high BP in pregnant and nonpregnant female rats.
It has been postulated that calcium uptake is inversely related to blood pressure (BP) in animals and pregnant women. To test this hypothesis, 34 female, 142-day-old Wistar rats were studied prospectively. They were randomly assigned to either a calcium-free diet (16 rats) or a normal diet (18 rats). Weekly measurements of tail systolic BP showed a statistically significant increase in BP in the calcium-free group after 6 weeks of treatment. After 9 weeks on this diet, the animals were mated. Five in the control group and six in the calcium-free group became pregnant. Thereafter, both of these subgroups (pregnant and nonpregnant calcium-free diet) continued with significantly higher BP until they were put to death. Blood samples taken at the end of the study showed significantly lower values of calcium/magnesium (Ca/Mg) ratio, but higher inorganic phosphate in the group consuming a calcium-free diet. Blood pressure during the last 3 weeks of the study was significantly inversely correlated with the blood Ca/Mg ratio and directly correlated with magnesium and inorganic phosphate values. This article supports the hypothesis that a low-calcium diet is associated with high BP in pregnant and nonpregnant female rats.