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Spindle-cell lipoma. A clinical, light- and electron-microscopical study
The American Journal of Surgical Pathology
|July 1, 1981
Summary
Spindle-cell lipomas, rare tumors in men, show two cell types under electron microscopy: mesenchymal and mature fat cells. These findings suggest a link between spindle cells and primitive fat lobule structures.
Area of Science:
- Surgical pathology
- Dermatopathology
- Tumor biology
Background:
- Spindle-cell lipoma is a benign soft tissue tumor.
- These tumors predominantly affect middle-aged men.
- Common locations include the posterior neck and upper back.
Purpose of the Study:
- To characterize the cellular composition of spindle-cell lipomas.
- To investigate the histological and ultrastructural features of these tumors.
- To propose a cellular origin for the spindle cells.
Main Methods:
- Light microscopy examination of five spindle-cell lipoma نمونهs.
- Electron microscopy analysis of tumor cell populations.
- Histological assessment of growth patterns.
Main Results:
- All five cases occurred in male patients.
- Tumors were located in subcutaneous tissues of the back, neck, or behind the ear.
- Electron microscopy revealed two distinct cell populations: spindled mesenchymal cells and mature lipocytes.
Conclusions:
- Spindle-cell lipomas exhibit diverse histological patterns.
- The presence of both mesenchymal and lipocytic cells suggests a dual cell origin.
- Spindled cells are hypothesized to be analogous to primitive stellate mesenchymal cells of the fat lobule.