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Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction
Published on: November 1, 2018
Epidemic dengue 3 in central Java, associated with low viremia in man
The American Journal of Tropical Medicine and Hygiene
|September 1, 1981
Summary
A 1978 dengue type 3 outbreak in Central Java showed mild illness and low viremia. This suggests endemic dengue virus strains can cause less severe disease, differing from previous explosive epidemics.
Area of Science:
- Virology
- Epidemiology
- Public Health
Background:
- Dengue virus type 3 outbreaks have historically caused severe illness.
- Previous epidemics in Central and East Java were explosive in nature.
Purpose of the Study:
- To investigate the characteristics of a dengue type 3 outbreak in Central Java in 1978.
- To compare this outbreak's features with previous dengue 3 epidemics.
Main Methods:
- Studied a dengue type 3 outbreak in Central Java, Indonesia, in 1978.
- Compared clinical presentation, viremia levels, and virus isolation rates with a prior epidemic.
Main Results:
- The 1978 outbreak was less explosive, with milder illness and lower viremia.
- Dengue virus isolation rate was 32% in confirmed patients, significantly lower than 65% in a 1977 epidemic.
- No correlation found between antibody titers or specimen collection day and the observed differences.
Conclusions:
- Naturally occurring, endemic dengue virus strains may be associated with low viremia.
- These endemic strains appear to cause generally mild illness in humans.
- This finding contrasts with the more severe presentations of previous dengue 3 epidemics.
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