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[Microaggregate formation in buffycoat-free packed red cells (author's transl)]
Der Anaesthesist
|August 1, 1981
Summary
Microaggregate filtration is crucial for buffy coat-free packed red blood cells (PRC). Even after processing, residual microaggregates necessitate microfiltration to prevent transfusion-related acute pulmonary failure.
Area of Science:
- Hematology
- Biomedical Engineering
- Transfusion Medicine
Context:
- Buffy coat-free packed red blood cells (PRC) are used to minimize transfusion risks.
- Stored whole blood contains higher levels of amorphous debris compared to PRC.
- Quality of buffy coat-free PRC can vary significantly due to residual debris.
Purpose:
- To quantify microaggregate amounts in buffy coat-free PRC.
- To evaluate the effectiveness of current filtration methods.
- To determine the necessity of microfiltration for buffy coat-free PRC.
Summary:
- Microaggregates in buffy coat-free PRC were measured using nylon mesh filters (200, 50, 20, 10 micrometers).
- Significant microaggregate amounts were retained on 20 and 10 micrometer filters, comparable to those on 200 micrometer filters.
- Buffy coat-free PRC quality shows considerable variation, with substantial microaggregates remaining even after processing.
Impact:
- Microfiltration below 40 micrometers is recommended for buffy coat-free PRC.
- Transfusion of buffy coat-free PRC through microfilters is advised to mitigate risks of transfusion-related acute pulmonary failure.
- This study highlights the importance of stringent filtration protocols in transfusion medicine.