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In vitro susceptibility of Capnocytophaga strains to 18 antimicrobial agents
Abstract:
Twenty-seven strains of capnocytophaga were tested for their susceptibility to 18 antimicrobial agents by an agar dilution technique. All strains were susceptible to achievable blood levels of penicillin G, cefaclor, cefoxitin, cefoperazone, moxalactam, clindamycin, chloramphenicol, and tetracycline. Most were susceptible to achievable levels of cefamandole, erythromycin, and metronidazole, and more than 10% were resistant to achievable levels of cephalexin and cephradine. With antimicrobial agents used in selective media, all strains were resistant to colistin, kanamycin, and nalidixic acid at commonly recommended concentrations of bacitracin and vancomycin.
Insights
Capnocytophaga strains showed susceptibility to penicillin G and several cephalosporins, clindamycin, chloramphenicol, and tetracycline. However, resistance was observed against colistin, kanamycin, and nalidixic acid.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Capnocytophaga are gram-negative bacteria implicated in various infections.
- Understanding their antimicrobial susceptibility is crucial for effective treatment.
Purpose of the Study:
- To determine the in vitro susceptibility of Capnocytophaga strains to a broad range of antimicrobial agents.
Main Methods:
- Agar dilution technique was employed to test 27 Capnocytophaga strains.
- Susceptibility was assessed against 18 different antimicrobial agents.
Main Results:
- All strains were susceptible to penicillin G, cefaclor, cefoxitin, cefoperazone, moxalactam, clindamycin, chloramphenicol, and tetracycline.
- Most strains were susceptible to cefamandole, erythromycin, and metronidazole.
- Resistance was noted for cephalexin, cephradine, colistin, kanamycin, and nalidixic acid.
Conclusions:
- Penicillin G and several broad-spectrum antibiotics are effective against Capnocytophaga in vitro.
- Emerging resistance to certain agents necessitates careful antibiotic selection for Capnocytophaga infections.