Correlations between DNCB skin hypersensitivity and leukocyte migration inhibition by DNCB-coated human erythrocytes

Correlations between skin hypersensitivity to DNCB and LMI in presence of lyophilized, DNCB-coated human erythrocytes were evaluated. False positive results were found in 2 out of 25 (8%) non-sensitized donors and false negative--in 5 out of 21 (24%) sensitized patients. In follow-up evaluation after topical DNCB sensitization significant MI was usually seen about 3 weeks after sensitization and only in a part of patients after 6-9 weeks. Time limitations in the application of LMI test for evaluation of effects of immunosuppressive treatment are discussed.