Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transcapillary refill in hemorrhage and shock

W R Drucker, C D Chadwick, D S Gann

    Archives of Surgery (Chicago, Ill. : 1960)
    |October 1, 1981
    PubMed
    Summary

    Hemorrhage triggers fluid and protein shifts into capillaries, driven by Starling forces. Restoration of blood volume involves interstitial fluid and protein movement, influenced by hormones and glucose.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Measuring plasminogen activator inhibitor activity in plasma by two enzymatic assays.

    Journal of biochemical and biophysical methods·2000
    Same author

    Electric cautery lowers the contamination threshold for infection of laparotomies.

    American journal of surgery·1998
    Same author

    Comparison of parathyroid imaging with technetium-99m-pertechnetate/sestamibi subtraction, double-phase technetium-99m-sestamibi and technetium-99m-sestamibi SPECT.

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine·1997
    Same author

    Report of a meeting on the epidemiology and control of glycopeptide-resistant enterococci.

    The Journal of hospital infection·1996
    Same author

    Impairment of blood volume restitution after large hemorrhage: a mathematical model.

    The American journal of physiology·1996
    Same author

    Flexible endoscopy for the diagnosis of esophageal trauma.

    The Journal of trauma·1996

    Area of Science:

    • Physiology
    • Hemodynamics
    • Fluid Balance

    Background:

    • Hemorrhage causes reduced cardiac output and increased peripheral resistance.
    • Blood volume restoration is crucial for recovery from hemorrhage.
    • Fluid and protein movement between interstitium and capillaries is key to volume restoration.

    Purpose of the Study:

    • To elucidate the mechanisms of fluid and protein shifts during hemorrhage.
    • To understand the role of Starling forces in post-hemorrhage recovery.
    • To investigate the contribution of interstitial fluid and solutes to plasma volume restoration.

    Main Methods:

    • Analysis of physiological responses to hemorrhage.
    • Examination of fluid and protein dynamics across capillary membranes.
    • Investigation of Starling forces and their influence on fluid shifts.
    • Assessment of solute and hormonal influences on interstitial fluid movement.

    Main Results:

    • Hemorrhage-induced changes in Starling forces drive fluid and protein shifts.
    • Capillary hydrostatic pressure decrease promotes rapid fluid movement into capillaries.
    • Interstitial albumin is a primary source for plasma protein restoration.
    • Solute movement, particularly glucose, from cells into the interstitium facilitates fluid return.

    Conclusions:

    • Starling forces are central to fluid and protein shifts post-hemorrhage.
    • Hormonal regulation and solute transport, especially glucose, are critical for restoring plasma volume.
    • Understanding these mechanisms is vital for developing effective hemorrhage management strategies.

    Related Experiment Videos